I think the key word is "work." Whatever you do from home will be a lot of work.
Most all of the work-at-home opportunities consist of marketing some product to others. You have your Creative Memories, Mary Kay, Tupperware, Pampered Chef, Shaklee, Prepaid Legal, Avon, Party Lite, etc. etc. ad nauseum.
So ask yourself, are you willing to market some product to others? Are you willing to go to sales meetings, learn about your product, cold call, call from a list, email, hold parties, sell to your friends and make new contacts? It really doesn't matter which product you sell (although you should sell something you believe in) you're going to be a salesperson. You're going to have to put some money into the "business" and you're going to have to work hard to make money out of it. There's nothing wrong with Multi-Level-Marketing schemes, you CAN make money but you will make out of it what you put in. And if you're not cut out for sales then you won't make anything.
The other work-at-home opportunities will depend on other skills you have. You could do data entry, call for Amvets or Purple Heart, proofread, etc. If you're crafty you could sell stuff on etsy.
You could also babysit or start your own at-home daycare.
I proofread, edit videos and sell crafts at home.
Good luck to you!