M.R.
I don't know how hard it will/will not be with the children being close in age my boys are 14 yrs apart and it was hard with me having to deal w/a teenager and his activities and a baby w/acid reflux and sick a lot. I wish i would of been able to have my kids closer in age but i tell you that they are very close and they are wonderful together.
As far as the depression, I dealt with that 1st hand. My youngest son's dad left when i was 14 weeks pregnant and disappeared until my son was nearly 6 months old. I was very depressed, he wasn't me to have an abortion, I had a lot of complications, i was in and out of the hospital. My Dr put me on meds and it did help but it made me to the point that i couldn't feel and i didn't like that. I am a very sensitive person and i didn't have any feelings at all but just be cautious and when and if you wean yourself off just do it slowly cause it will make you an emotional roller coaster if you don't. Good Luck and I hope this helps.
M.