I feel your pain! My house got so out of control that I hired someone to come every other week for about 3 months to help me get it back under control.
I, too, LOVE Flylady.net and am really starting to commit to it. It is honestly the best of the online programs I've seen. Some of my favorite tips are:
Set your timer for 10 mintues and vac, sweep, mop, dust, or whatever -- do it for 10 mins and call it good enough
Spend 5 mins a day in the worst room and in just a few days you will see a HUGE improvement
Start a load of laundry every day before you go to work, dry it while cooking dinner, and fold & put it away during bath time
Invest in a Swiffer WetJet. It cuts mopping time in 1/2
I clean the tub/shower while I'm in there. I do it first so I can make sure I get all of the cleaner off of me. It is SO much easier to do it in there than try to get all the angles from the outside.
If you have specific areas you are looking for help in -- send me a message. I've been there and done that and may have something I can pass along to you.
Good Luck!