D.D.
I had a resistant E. Coli infection and was also treated with macrobid, once daily. I have had chronic UTIs my whole life though and this antibiotic is especially good because it has a low rate of resistance and is safe in pregnancy and while breast feeding. The incidence of resistant infections is on the rise, especially if you have taken antibiotics in the recent past, so best thing to do is take the antibiotics since UTI can lead to premature deliveries (not to mention discomfort to you!). Try to keep clean/shower daily and urinate whenever you have to go. Drink lots of fluids and stay out of baby pools (where I got mine!!!). Good luck and hang in there!