Hi L., I too have a bed-wetter. She's 8. We've been through everything trying to figure out what is causing it. Unfortunately, there is no answer. She's just a very heavy sleeper and doesn't wake up in the middle of the night to use the bathroom. I don't let her drink after 7pm and she uses the bathroom before her bedtime, but it still happens. I know that it's frustrating, but you have to try to keep your chin up and a smile on your face for his sake. Complaining about it in front of him or continuously talking to him about it can cause him more stress and make the problem worse. You said that he is your sister's son. Maybe the core of his problem is not having his mom around. Try a counseling session (together). If nothing else, maybe the counselor can recommend a new tactic for you. My daughter wears Goodnights, but sometimes she really wants to try to make it through the night without one. I never discourage her, so I bought wee-wee pads (what you would use for an animal) and put them under her sheets. It helps to protect the mattress. My pediatrician just recommeded that I wake my daughter up at 1am everyday and have her use the bathroom. We're hoping that her body will eventually get used to waking at that time and she's start to do it on her own. It's tiring for me to have to set the alarm and get up, but I'm sure you know that as a mom we all go to the ends of the earth for our children. Good luck to you and remember that one day he will grow out of it.