Hi K. -
Here are some links to check out the local schools. Our kids go to a Cherry Creek school and we have been very pleased. However, there are a couple that are not rated very well and some parents are not happy with them. http://www.greatschools.net/modperl/go/CO and http://www.psk12.com/rating/USindexphp/STATE_CO.html
As for neighborhoods we prefer the Highlands Ranch and Homestead areas. The Homestead are (Quebec/Dry Creek in Centennial is a great place to live. A little on the expensive side, but a GREAT community). It is so close to the the Denver Tech Center and all shopping. The main artery I-25 is very close and getting to Downtown, Castle Rock and Colorado Springs is super easy. We rarely go outside of our 5 mile radius because everything we need is right here.
When looking for schools ask other parents that have kids attending what they think. My kids' school has an occupational and speech therapist that are part of the school program as well as a psychologist. They work with the teachers so if your child needs a little extra help it is all within the school and it is set up where the kids don't have a clue they are getting the extra help. I've heard horror stories of parents being told to take there kids with any type of issue to seek outside tutoring or put them on drugs. Definitely make sure the school is geared towards helping your child grow and learn in all aspects of life and that they have a support system within the school.
I'm sure you can build your business anywhere you go. I would suggest seeking Cherry Creek, Lone Tree, and Highlands Ranch for the south of Denver. East Aurora is building up nicely and there are many higher priced homes as well that may be apt to use your services.
Here is a link for finding some homes.
http://www.cohomefinder.com.
I wish you luck in your move and keep us updated. We have a great community of moms and families here in Denver, you will love it!