Sleeping Habits: Preschooler, Benadryl

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Help! My 3 YO Niece Never Sleeps!!!

My sister and her two daughters - 3 and 4 live me. The 3 YO doesn't SLEEP! All hours of the morning she's roaming the house! I'm talking 2AM, 4AM, etc. Sometimes she wakes the 4 YO. The one bad thing is that my sis, when she's asleep, she's "dead" to the world so they come and bother me. The daycare has kept her awake during nap time to help, but this doesn't work! She's up at daycare at 6AM everyday. What can I do to make her SLEEP! HONESTLY, I thought about Benadryl, but she's too young!!!