Personally, I agree with Kelly K. it all depends on the kid. Being a naive first time Mom I had not done my research on vaccines at ALL. That is until after my first son's 2 month well baby visit. He had all of the standard 2month check up vaccines. I think it was a total of 2 shots but 7 vaccines. His reaction baffled me and scared me to know end. He cried endlessly, stared blankly and was refusing to eat, along with a fever. All which they say are "normal" reactions. Are you kidding me? Then I started thinking back to when I first brought him home from the NICU they had done the HEPB vaccine and by day two he was screaming and just horribly cranky and wouldn't calm down at all. I took him in saying somethings wrong help, and they thought it was something else did some testing and everything came back fine. In retrospect I believe it was definitely a reaction to the vaccine.
With him I continued an alternative schedule until he was 2.5. He always spikes fevers and is generally beyond uncomfortable. In fact, just at his 3 year check up they said he needed another Prevnar. Confused, but caught off guard because I though we were done I said go ahead. Guess what, 104 fever for 2 days and he couldnt walk for 3 days. No bueno! And this was all because in 2010 they added 6 more strains to the vaccine, so it was just a "booster" to expose him to the additions. But that was my fault for not just declining and taking the advise of the nurse.
Now with that said my 2nd son (18mths), hasn't had one fever, or even the typical crankiness, rash or anything. Didn't even phase him. In fact, the first 6 months he didn't even wince, when they gave the shot. Based off of those results, I only did the alternative schedule to the point where I knew how he reacted to each set of vaccines, so by 9 months I was basically up to par with the recommended schedule and will continue to follow that schedule here on out (well excluding Hep B vaccines and that's because I have MS and there is a lot of anecdotal evidence that suggests Hep B may be an environmental trigger for it). Unless something drastically changes, his body seems to tolerate them better than my first...but then again he was a lot bigger of a baby than my first too!
Good luck in whatever decision you decide to follow.