C.H.
hit no, then open (im assuming your using a pc, macs don't do that...) my computer, and find your E drive, i think, it should have the name of the brand your usb is, unless you renamed it (then look for the name you gave it) and then it should open. otherwise search the name of your documents/pictures/whatever in my documents.
that should work.
and yes you can transfer from pc to mac, mac to pc isn't as easy, but usb's do work, just have to export file to a format recognized on the other computer, (Mac- say you used pages, export, select word document, and it saves it as a word document. otherwise macs can open almost anything