N.L.
The schools promise in their advertising that employers won't care but it's not true. Nothing replaces hands on experience and learning that takes place through live examples and interactions in the classroom. Professionals know this and will judge accordingly- that is the unadulterated truth. And also, it depends what kind of degree. The more it has to do with people (sales, social work, etc.) the more it's important to be live schooling. IF it's a technical type training (reading sonograms, fixing computers) there is more leeway.
That being said, the best thing you can do if you are looking for a way to make this happen and can't commit the time of all live classes is to have a mix. Enroll in a school that can offer on-line classes for certain classes and live ones for others. So University of Phoenix is a horrible choice b/c everyone knows it to be primarily on-line. But, Fordham or a SUNY/CUNY school is pretty good b/c they have decent reputations and yet can offer you a variety of options that may include on-line. Good luck!