K.S.
We found that Ibuprofen was the biggest help, although the eye teeth and molars where basically just miserable. We also tried alternating Iboprofen with Tylenol, but it was pretty obvious which helped better. I know many people who swore by the Hyland Tablets, but no matter how we gave them, they did nothing for our son. I would advise against the Orajel unless you REALLY are certain it is helping. Our doctor told us she did not recommend using it. That one of the ingredients can alter your child's heart rate. Since it did not help our son, and WAY ticked him off, I threw it away.
During the day, distraction was our best medicine. Keeping him busy and entertained. It's exhausting, but at least at 16 months there ARE lots of fun things to do. You could prehaps use Tylenol during the day as well. Then at night and nap times we would give the Ibuprofen, with some food or milk to try to help prevent any tummy discomfort. I would give it to him about 20-30 minutes before bed, then if he woke up and it was 6 hours or more later since the first dose. I felt like I was medicating him way too much for quite a while. But the other option was to have him miserable and not sleeping, which was awful. When there seemed to be a little break from the teething, I would stop the meds for a while, until he needed them again. Good luck...you'll get through this, really!