No advice other than a tip. All of the non-smoking rooms (in the hotels with casinos especially) are smokey! It comes through the vents from other places! In fact, everywhere you go, even outside, smoke! I'm real sensitive to cig smoke and was miserable the last time I was in Vegas....literally counting the days til I could get away from the cig smoke. I don't know if this is still the case since it was a while ago I was last there (about 8 years now)
Anyhoo, that trip was work related, so I had no choice on accommodations, though very nice (The Monte Carlo) I probably would have found another place to stay, far from the casinos/strip and would have been quite happy just driving in to site see.
If I were going with family, and this is an issue considering there will be kids and possibly elderly depending on who family-wise is coming along, I'd rent a nice luxury RV. You maybe will have more options of places to go and things to see being mobile, and you'd definitely avoid the smoke.