That is really a huge question!
First, allow me to say that I mean no disrespect to the other women who have answered. The thing is, they are both in (what sounds like) direct marketing / sales. It is a very hard field to "make it" in. A very small percentage of people are really cut out to be in that kind of business. Plus, many times, you end up spending "x" amount of money on the products (and marketing) before you can even start selling and making money. THEN you have to find the right person that will actually buy your product...
Anything that you are going to make money with from home is going to come from your own brain. Get your thinking cap on - what do you love to do? How can you do that cheaper and better than most others? What do the people in your neighborhood need / want? What service can you offer? (Service businesses are typically much cheaper to run than product businesses. ESPECIALLY if YOU can provide the service yourself!)
Don't let the "economy" scare you either. People still have money, and they are still spending it. They are just spending it a little more wisely. You need to spin, whatever it is that you are selling, into something that your customer will not mind spending their money on.
Please, trust me on this! I have tried so many work from home things. I have bought into a business, I have bought information to tell me about a business, I have tried some really crazy ideas that I came up with! It can be a process - perhaps you will get lucky on your first venture.
Just keep your spending down. WAY DOWN! You are doing this to earn extra money - not spend it! :)
I could go on forever on this topic. If you want to, send me a private message and I can help you further...