Hi J., I am not sure what these spots might be; however, Shaklee has a laundry booster called Nature Bright that is a fantastic stain fighter -- it is Shaklee's answer to bleach (which is sooo bad for us). Nature Bright is non-toxic so is safe for us and for the environment. I would try mixing one scoop of Nature Bright in a laundry sink of warm water and then add the spotted garments. Let them soak totally under water for a few hours (or overnight). Wring them out and throw them in the washer. This time, I would try Shaklee's non-toxic laundry detergent - you only use a little as all their cleaning products are heavily concentrated -- this saves you money also as they last longer). Then add one scoop of Nature Bright right on top of the detergent in the dispenser cup of your washer. I think this might get rid of those spots, although I am not sure what they are. You don't mention what brand of detergent you have been using, but I am wondering if that could be the culprit. Please contact me with other questions on this, as I am a Shaklee distributor and enjoy helping to solve problems. Also feel free to browse my site at www.emilytaft.com and read about the Nature Bright and the laundry detergent. My contact info is ###-###-#### and ____@____.com Best Wishes. E. Taft