Find his college's webpage. They should have a link or info regarding the area. From there you can find restaurants or some other activity in the area (like movies, bowling, skating, etc). Get him a gift certificate for one of them (either a national chain or a local hot spot). If that doesn't work, you could call the college and just ask what is in the area. My son is between his Jr and Sr year in college and just turned 21 and these have always been some of his favorite gifts. Especially the first one we got for his favorite local pizza place (and he was quite surprised by it too).
Another option is to get a gift certificate for the school book store...he can use it for books, college logo things, snacks, etc.
Does he have a car?...gas cards are always helpful.