I do this trip about once a year or so. My parents live 30 minutes from Tallahassee. Basically, we take i-20 to us-49. There may be faster routes, but we like traveling the familiar. And many times (like this summer), I am traveling alone with the kids and I want to stay around major cities and not off the beaten path in case I run into car troubles. I think the roads we take are fine...Louisiana often leaves something to be desired in the highway dept, but I remember improvements there on our last trek through.
When I travel with my husband, we take shifts and drive straight through. When I am alone, I basically drive until I can't any longer and get a hotel room for the night. I pick from the better known chain motels places and I haven't run in to many issues along the way. We don't necessarily love the drives together, I mean really, who WANTS to drive 17 hours? But we enjoy the destination and the uninterrupted time together.
As far as entertaining kiddos. I fill a little basket next to each kid with a few items. I try to make them things without a lot of pieces. Younger kids drop things and then need help finding it. Things get lost, kids get upset, etc. So things like mp3 players (with kid headphones so they can't turn it up to loud) filled with music and stories. Etch a sketch, magnadoodles. Books or magazines. I avoid crayons and coloring...we had an incident with red and pink crayons that melted in the carpeting. Snacks, snacks and more snacks. Find it tubes. I try to keep things at a minimum and choose things that will really entertain my kiddos.
I have soft trays (so they are safe in case of an accident) that clip to the seatbelts, so they don't slide off. These are great for snack tables and playing on. At one point my son loved playing with hot wheels cars. Since the sides of the trays are raised, the cars stayed put. My son is 7 now and he will remind us to pack the trays because he likes them so much.
The last time I traveled by myself a momma on hear suggested a surprise bag. I went to the dollar store and clearance items and got a few surprises. When kids got bored or fussy, I would pull something out. It was a great distraction, especially for my youngest who was 2 the last time I drove it alone.
Take lots of little breaks. I bring a ball on every trip and try to use rest stops. That way the kids can run and play in the grass for a little bit. A little run will help make the trip much easier. And we don't really do fast food very often, but on these trips almost every meal stop involves a playground. It's special treat for the kids and again, gives them a chance to run and play. And we usually stay a motels or hotels with swimming pools. We hit that up before bed. It helps wear kids out and make bedtime easier.
Safe travels!
ETA...we do NOT like leaving at bedtime or traveling at night. It makes us tired and the kids never sleep well, so they are crank pots all day. Personally, my night vision isn't all that terrific either. I know friends who love traveling at night. It just doesn't work for us.