What are your skills? What volunteer work have you done that may translate into a workplace? Have you organized things at the school, done projects for church, run a Scout troop, planned plays or recitals, helped out at a nursing home or senior center? Make a list of your skills (organization, fundraising, publicity for events, data entry for school rosters or similar, budgeting, meal preparation for more than your family, carpool organization (more than just your own kids). Then sit down with 3 friends and get them to make a list of your skills and attributes.
Look at resume templates and ways to do a skills-based resume rather than a chronological employer-based resume. There are lots of people who consult on this sort of work - I have a friend who does it, for example, and her big selling point is that she has a 95% "success rate" (meaning she gets 95% of her clients into an interview, so that means their resumes got noticed. She also does interview prep. There are a lot of HR people who do this, and also life coaches who specialize in this work. You have to be willing to invest a little money in this, but it's usually deductible and you'll make it up on the other end.
Do you still have kids at home and do you need a school calendar-based job? Start with a job at the school (even cafeteria worker) or bus driver. If not, look at temp agencies - lots of companies will do a temp-to-permanent trial period.
You should also figure out your goals - do you want a salary, or do you want to prove yourself with your own business? I wasn't clear from your last sentence what your aspirations are.